Hypersensitivity to the drug group cephalosporins and other beta-lactam antibiotics
not prescribed newborns (up to 1 month). Pregnancy and lactation : Pregnant appoint only testosterone cypionate injections strict indications, treatment is carried out under the supervision of a physician. If necessary, use of the drug in lactating women breastfeeding stopped.
preparation of solutions:
for intramuscular administration, the preparation was dissolved in 4.5 ml of water for injection, isotonic sodium chloride solution or novocaine solution, 0.25-0.5% .
For intravenous drip of the drug is dissolved in 100-250 ml of isotonic sodium chloride solution or 5% glucose solution; injection is carried out for 20-30 minutes (introduction rate of 60-80 drops per minute).
For intravenous single bolus dose of 10 ml diluted in an isotonic sodium chloride solution and administered slowly over 3-5 minutes.
During the cultivation flasks shaken vigorously until complete dissolution.
Side effects: Allergic reaction : pyrexia, rash, urticaria, pruritus, bronchospasm, eosinophilia, angioedema, arthralgia, anaphylactic shock, erythema multiforme, a malignant exudative erythema (Stevens-Johnson syndrome). From the nervous system : convulsions. Urinary system : patients with kidney disease when treatment with high doses (6 g) – impaired renal function (in these cases, the dose reduced, and treatment is carried out under the control of the dynamics of urea nitrogen and creatinine in the blood). from the digestive system : nausea, vomiting, diarrhea , abdominal pain, pseudomembranous enterocolitis, rarely – cholestatic jaundice, hepatitis. From the side of hematopoiesis : leukopenia, neutropenia, thrombocytopenia, thrombocytosis, haemolytic anemia. in the long-term treatment – goiter, superinfection, caused by antibiotic-resistant strains, candidiasis testosterone cypionate injections (including. h thrush).. Laboratory findings : positive Coombs’ test, increased activity of “liver” transaminases, hypercreatininemia, increased prothrombin time. Local reactions : when i / m administration – pain (in the introduction), with a / in the introduction – phlebitis.
Interaction with other medicinal products
is not recommended with concomitant use of anticoagulants and diuretics. With simultaneous use of cefazolin and “loop diuretics” derives its blockade of tubular secretion.
Aminoglycosides increase the risk of kidney damage. The solution is pharmaceutically incompatible with aminoglycosides (mutual inactivation).
Drugs that block tubular secretion, increase the concentration in the blood, slow elimination and increase the risk of toxic reactions.
Patients who had a history of allergic reactions to penicillins, carbapenems may be sensitive to cephalosporin antibiotics.
During treatment with cefazolin is possible to obtain positive direct and indirect Coombs’ samples, as well as false-positive sugar reaction of urine.
In appointing the drug may increase gastrointestinal diseases, particularly colitis.
Health and Safety in preterm infants and infants has not been established.
Powder for solution for intravenous and intramuscular administration, and 0.5 g 1 g
0.5 g and 1.0 g of active substance in glass vials of 10 ml capacity.
Solvent – “Water for injection” in glass ampoules 5 ml .
1 vial and instructions for use are placed in a pile of cardboard.
1 vial and 1 ampoule of solvent is packaged in blisters. One contour cell package and instructions for use are investing in paper cartons.
5 vials of the drug is packaged in blisters. One contour cell package and instructions for use are investing testosterone cypionate injections in paper cartons.
5 vials of medication, complete with 5 ampoules of solvent is packaged in blisters. One contour cell package with the drug one contour cell package with a solvent, and instructions for use are investing in paper cartons. helios steroids